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Bedaquiline drug was developed to treat which of the following diseases?

 Bedaquiline drug was developed to treat which of the following diseases?

Acute Myeloid Leukemia
Correct Answer

The correct answer is MDR-TB.

Key Points

  • Bedaquiline is used specifically to treat MDR-TB patients.
  • MDR-TB stands for Multidrug-resistant tuberculosis. In this specific type of TB, the patient is resistant to the common drugs that are used to treat TB. 
  • The most common medications used to treat tuberculosis are Isoniazid, Rifampin (Rifadin, Rimactane), Ethambutol (Myambutol), Pyrazinamide.
  • Bedaquiline was discovered by a team led by Koen Andries at Janssen Pharmaceutica.

Important Points

Acute Myeloid Leukemia
  • It is a cancer of the blood and bone marrow.
  • With AML, the bone marrow makes abnormal blood cells including:
    • Myeloblasts—a stem cell that evolves into specific types of white blood cells that help the body fight infection.
    • Red blood cells (RBCs)—carry oxygen.
    • Platelets—a blood component involved in clotting blood.
  • Treatment of AML usually involves 2 phases:
    • Remission induction therapy—to kill leukaemia cells.
    • Maintenance therapy—to kill any remaining leukaemia cells that could grow and cause a relapse.
  • Cholera is a bacterial infection.
  • They grow and release a toxin in the small bowel. You get it when you drink water or eat food that had contact with infected human stool.
  • Diarrhoea causes rapid fluid loss.
  • Cholera is common in places that don’t have proper sewage treatment.
  • Osteoarthritis (OA) is the wearing down of the cartilage between bones.
    • Cartilage is smooth tissue that cushions bones and helps them move smoothly over each other.

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