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Bedaquiline drug was developed to treat which of the following diseases?

 Bedaquiline drug was developed to treat which of the following diseases?

1
Acute Myeloid Leukemia
2
Cholera
3
MDR-TB
Correct Answer
4
Osteoarthritis

The correct answer is MDR-TB.

Key Points

  • Bedaquiline is used specifically to treat MDR-TB patients.
  • MDR-TB stands for Multidrug-resistant tuberculosis. In this specific type of TB, the patient is resistant to the common drugs that are used to treat TB. 
  • The most common medications used to treat tuberculosis are Isoniazid, Rifampin (Rifadin, Rimactane), Ethambutol (Myambutol), Pyrazinamide.
  • Bedaquiline was discovered by a team led by Koen Andries at Janssen Pharmaceutica.

Important Points

Acute Myeloid Leukemia
  • It is a cancer of the blood and bone marrow.
  • With AML, the bone marrow makes abnormal blood cells including:
    • Myeloblasts—a stem cell that evolves into specific types of white blood cells that help the body fight infection.
    • Red blood cells (RBCs)—carry oxygen.
    • Platelets—a blood component involved in clotting blood.
  • Treatment of AML usually involves 2 phases:
    • Remission induction therapy—to kill leukaemia cells.
    • Maintenance therapy—to kill any remaining leukaemia cells that could grow and cause a relapse.
Cholera
  • Cholera is a bacterial infection.
  • They grow and release a toxin in the small bowel. You get it when you drink water or eat food that had contact with infected human stool.
  • Diarrhoea causes rapid fluid loss.
  • Cholera is common in places that don’t have proper sewage treatment.
Osteoarthritis
  • Osteoarthritis (OA) is the wearing down of the cartilage between bones.
    • Cartilage is smooth tissue that cushions bones and helps them move smoothly over each other.
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